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Side-chain, side chain, or sidechain may refer to:
- Side chain, a chemical group attached to the main chain or backbone of a molecule, such as a protein
- Substituent, an atom or group of atoms substituted in place of a hydrogen atom on the parent chain of a hydrocarbon
- Side-chaining, an effect in digital audio processing
- Sidechain (ledger), a designation for a particular blockchain
| disambiguation page lists articles associated with the title Side-chain.
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